A Comprehensive Superposition of Viral Polymerase Structures.

ABSTRACT: Nucleic acid polymerases are essential enzymes that replicate the genomes of both RNA and DNA viruses. These enzymes are generally encoded by viruses themselves so as to provide biochemical functions and control elements that differ from those of the host cell polymerases. The core active site structure used by all replicative polymerases is highly conserved and composed of two key aspartate residues from the conserved motifs A and C, but beyond this there is significant divergence among structures. These differences can make it difficult to select which portions of structures to align for comparisons, yet there are extended structural similarities within different groups of viral polymerases that should clearly be considered to generate optimal alignments. This manuscript describes a comp

SUBMITTER: Peersen OB 

PROVIDER: S-EPMC6723251 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature