Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition.

ABSTRACT: Protein and branched-chain amino acid (BCAA) intake are associated with changes in circulating BCAAs and influence metabolic health in humans and rodents. However, the relationship between BCAAs and body composition in both species is unclear, with many studies questioning the translatability of preclinical findings to humans. Here, we assessed and directly compared the relationship between circulating BCAAs, body composition, and intake in older mice and men. Body weight and body fat were positively associated with circulating BCAA levels in both mouse and human, which remained significant after adjustments for age, physical activity, number of morbidities, smoking status, and source of income in the human cohort. Macronutrient intakes were similarly associated with circulating BCAA level

SUBMITTER: Ribeiro RV 

PROVIDER: S-EPMC6723310 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature