A Milled Microdevice to Advance Glia-Mediated Therapies in the Adult Nervous System.

ABSTRACT: Neurodegenerative disorders affect millions of adults worldwide. Neuroglia have become recent therapeutic targets due to their reparative abilities in the recycling of exogenous neurotoxins and production of endogenous growth factors for proper functioning of the adult nervous system (NS). Since neuroglia respond effectively to stimuli within in vivo environments on the micron scale, adult glial physiology has remarkable synergy with microscale systems. While clinical studies have begun to explore the reparative action of Müller glia (MG) of the visual system and Schwann Cells (ShC) of the peripheral NS after neural insult, few platforms enable the study of intrinsic neuroglia responses to changes in the local microenvironment. This project developed a low-cost, benchtop-friendly microflui

SUBMITTER: Pena JS 

PROVIDER: S-EPMC6723365 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature