Hydrodynamics of Intravitreal Injections into Liquid Vitreous Substitutes.

ABSTRACT: Intravitreal injections have become the cornerstone of retinal care and one of the most commonly performed procedures across all medical specialties. The impact of hydrodynamic forces of intravitreal solutions when injected into vitreous or vitreous substitutes has not been well described. While computational models do exist, they tend to underestimate the starting surface area of an injected bolus of a drug. Here, we report the dispersion profile of a dye bolus (50 µL) injected into different vitreous substitutes of varying viscosities, surface tensions, and volumetric densities. A novel 3D printed in vitro model of the vitreous cavity of the eye was designed to visualize the dispersion profile of solutions when injected into the following vitreous substitutes-balanced salt solution (BSS)

SUBMITTER: Henein C 

PROVIDER: S-EPMC6723562 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature