The Impact of Salts on the Ice Recrystallization Inhibition Activity of Antifreeze (Glyco)Proteins.

ABSTRACT: Antifreeze (glyco)proteins (AF(G)Ps) have received increasing attention as potential cryopreservation agents since their discovery in the 1970s. While cryopreservation strategies for specific cells (such as red blood cells) are successful and widely implemented, preservation of other cell types, tissues and whole organs remains challenging. This is due to the multifactorial nature of the freeze-thaw damage, the complexity of preserving biological matter and the (country-to-country) variability of the employed procedures and regulations. AF(G)Ps are well-known for their ability to modulate ice crystal growth morphology and ice recrystallization inhibition (IRI), both of which are considered key contributors to freeze-thaw damage. To date, however, the impact of AF(G)Ps on cell survival rema

SUBMITTER: Suris-Valls R 

PROVIDER: S-EPMC6724029 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature