Inhibitory Effects of Antiviral Drug Candidates on Canine Parvovirus in F81 cells.

ABSTRACT: Canine parvovirus (CPV) is a common etiological agent of acute enteritis, which occurs globally in domestic and wild carnivores. Despite the widespread use of inactivated or live attenuated vaccines, the emergence of antigenic variants and the influence of maternal antibodies have raised some concerns regarding the efficacy of commercial vaccines. While no specific antiviral therapy for CPV infection exists, the only treatment option for the infection is supportive therapy based on symptoms. Thus, there is an urgent medical need to develop antiviral therapeutic options to reduce the burden of CPV-related disease. In this study, a cytopathic effect (CPE)-based high-throughput screening assay was used to screen CPV inhibitors from a Food and Drug Administration (FDA)-approved drug library. A

SUBMITTER: Zhou H 

PROVIDER: S-EPMC6724046 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature