Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical-Chemical Characterization in View of Biological Applications.

ABSTRACT: Silver nanoparticles (AgNPs) are widely used as antibacterial agents and anticancer drugs, but often their low stability limits their mass production and broad applications. The use of niosomes as a carrier to protect and envelop AgNPs gives a new perspective to solve these problems. In this study, AgNPs were functionalized with sodium 3-mercapto-1-propanesulfonate (3MPS) to induce hydrophilic behavior, improving loading in Tween 20 and Span 20 niosomes (NioTw20 and NioSp20, respectively). Entrapment efficiency was evaluated by UV analyses and is around 1-4%. Dimensions were investigated by means of dynamic light scattering (DLS) (<2R_H> = 140 ± 4 nm and <2R_H> = 251 ± 1 nm respectively for NioTw20 + AgNPs and NioSp20 + AgNPs) and were compared with those by atomic forc

SUBMITTER: Rinaldi F 

PROVIDER: S-EPMC6724070 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature