Associations of Chronic Inflammation, Insulin Resistance, and Severe Obesity With Mortality, Myocardial Infarction, Cancer, and Chronic Pulmonary Disease.

ABSTRACT:

Importance

Chronic inflammation and insulin resistance often accompany severe obesity, and all are associated with disease risk.

Objective

To examine how the association of severe obesity with adverse outcomes may be modified by the presence of systemic inflammation and/or insulin resistance.

Design, setting, and participants

This population-based, retrospective cohort study included all residents of Alberta, Canada, aged 18 years and older with at least 1 procedure to ascertain severe obesity and measures of C-reactive protein, fasting glucose, triglyceride, and high-density lipoprotein cholesterol levels. Participants were observed from April 2003 to March 2017, and data analysis was conducted from June 2018 to December 2018.

Exposures

Severe obesity (body ma

SUBMITTER: Wiebe N 

PROVIDER: S-EPMC6724168 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature