Pre-Analytical Factors that Affect Metabolite Stability in Human Urine, Plasma, and Serum: A Review.

ABSTRACT: Metabolomics provides a comprehensive assessment of numerous small molecules in biological samples. As it integrates the effects of exogenous exposures, endogenous metabolism, and genetic variation, metabolomics is well-suited for studies examining metabolic profiles associated with a variety of chronic diseases. In this review, we summarize the studies that have characterized the effects of various pre-analytical factors on both targeted and untargeted metabolomic studies involving human plasma, serum, and urine and were published through 14 January 2019. A standardized protocol was used for extracting data from full-text articles identified by searching PubMed and EMBASE. For plasma and serum samples, metabolomic profiles were affected by fasting status, hemolysis, collection time, proce

SUBMITTER: Stevens VL 

PROVIDER: S-EPMC6724180 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature