Orthogonal Dietary Niche Enables Reversible Engraftment of a Gut Bacterial Commensal.

ABSTRACT: Interest in manipulating the gut microbiota to treat disease has led to a need for understanding how organisms can establish themselves when introduced into a host with an intact microbial community. Here, we employ the concept of orthogonal niche engineering: a resource typically absent from the diet, seaweed, creates a customized niche for an introduced organism. In the short term, co-introduction of this resource at 1% in the diet along with an organism with exclusive access to this resource, Bacteroides plebeius DSM 17135, enables it to colonize at a median abundance of 1% and frequently up to 10 or more percent, both on pulsed and constant seaweed diets. In a two-month follow-up after the initial treatment period, B. plebeius stops responding to seaweed in mice initially on the consta

SUBMITTER: Kearney SM 

PROVIDER: S-EPMC6724203 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature