The effects of chronic alcohol self-administration in nonhuman primate brain networks.

ABSTRACT:

Background

Long-term alcohol abuse is associated with change in behavior, brain structure, and brain function. However, the nature of these changes is not well understood. In this study, we used network science to analyze a nonhuman primate model of ethanol self-administration to evaluate functional differences between animals with chronic alcohol use and animals with no exposure to alcohol. Of particular interest was how chronic alcohol exposure may affect the resting state network.

Methods

Baseline resting state functional magnetic resonance imaging was acquired in a cohort of vervet monkeys. Animals underwent an induction period where they were exposed to an isocaloric maltose dextrin solution (control) or ethanol in escalating doses over three 30-day epochs. Following in

SUBMITTER: Telesford QK 

PROVIDER: S-EPMC6724209 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature