The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.

ABSTRACT: Mutations in natriuretic peptide receptor 2 (Npr2) gene cause a rare form of short-limbed dwarfism, but its physiological effects have not been well studied. Human and mouse genetic data suggest that Npr2 in the kidney plays a role in salt homeostasis. Herein, we described anatomic changes within renal papilla of Npr2 knockout (Npr2^-/-) mice. Dramatic reduction was found in diuresis, and albuminuria was evident after administration of 1% NaCl in drinking water in Npr2^-/- and heterozygous (Npr2^+/-) mice compared with their wild-type (Npr2^+/+) littermates. There was indication of renal epithelial damage accompanied by high numbers of red blood cells and inflammatory cells (macrophage surface glycoproteins binding to galectin-3) and an increase of r

SUBMITTER: Dugbartey GJ 

PROVIDER: S-EPMC6724224 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature