Maternal age at menarche and offspring body mass index in childhood.

ABSTRACT:

Background

Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear.

Methods

In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI.

Results

A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associate

SUBMITTER: Wang H 

PROVIDER: S-EPMC6724332 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature