Inhibitory effect of purple rice husk extract on AFB₁-induced micronucleus formation in rat liver through modulation of xenobiotic metabolizing enzymes.

ABSTRACT:

Background

Rice husk, a waste material produced during milling, contains numerous phytochemicals that may be sources of cancer chemopreventive agents. Various biological activities of white and colored rice husk have been reported. However, there are few comparative studies of the cancer chemopreventive effects of white and colored rice husk.

Methods

This study investigated the cancer chemopreventive activities of two different colors of rice husk using in vitro and in vivo models. A bacterial mutation assay using Salmonella typhimurium strains TA98 and TA100 was performed; enzyme induction activity in murine hepatoma cells was measured, and a liver micronucleus test was performed in male Wistar rats.

Results

The white rice husk (WRHE) and purple rice husk (PRHE) extr

SUBMITTER: Chariyakornkul A 

PROVIDER: S-EPMC6724366 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature