Inflammatory pathways are central to posterior cerebrovascular artery remodelling prior to the onset of congenital hypertension.

ABSTRACT: Cerebral artery hypoperfusion may provide the basis for linking ischemic stroke with hypertension. Brain hypoperfusion may induce hypertension that may serve as an auto-protective mechanism to prevent ischemic stroke. We hypothesised that hypertension is caused by remodelling of the cerebral arteries, which is triggered by inflammation. We used a congenital rat model of hypertension and examined age-related changes in gene expression of the cerebral arteries using RNA sequencing. Prior to hypertension, we found changes in signalling pathways associated with the immune system and fibrosis. Validation studies using second harmonics generation microscopy revealed upregulation of collagen type I and IV in both tunica externa and media. These changes in the extracellular matrix of cerebral arte

SUBMITTER: Walas D 

PROVIDER: S-EPMC6724458 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature