Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations.

ABSTRACT:

Objective

Young adulthood is a crucial neurodevelopmental period during which impulsive and compulsive problem behaviours commonly emerge. While traditionally considered diametrically opposed, impulsive and compulsive symptoms tend to co-occur. The objectives of this study were as follows: (a) to identify the optimal trans-diagnostic structural framework for measuring impulsive and compulsive problem behaviours, and (b) to use this optimal framework to identify common/distinct antecedents of these latent phenotypes.

Method

In total, 654 young adults were recruited as part of the Neuroscience in Psychiatry Network, a population-based cohort in the United Kingdom. The optimal trans-diagnostic structural model capturing 33 types of impulsive and compulsive problem behaviours wa

SUBMITTER: Chamberlain SR 

PROVIDER: S-EPMC6724459 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature