Sonoporation of Cells by a Parallel Stable Cavitation Microbubble Array.

ABSTRACT: Sonoporation is a targeted drug delivery technique that employs cavitation microbubbles to generate transient pores in the cell membrane, allowing foreign substances to enter cells by passing through the pores. Due to the broad size distribution of microbubbles, cavitation events appear to be a random process, making it difficult to achieve controllable and efficient sonoporation. In this work a technique is reported using a microfluidic device that enables in parallel modulation of membrane permeability by an oscillating microbubble array. Multirectangular channels of uniform size are created at the sidewall to generate an array of monodispersed microbubbles, which oscillate with almost the same amplitude and resonant frequency, ensuring homogeneous sonoporation with high efficacy. Stable

SUBMITTER: Meng L 

PROVIDER: S-EPMC6724477 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature