CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells.

ABSTRACT: The centrosome, composed of two centrioles surrounded by pericentriolar material, is the cell's central microtubule-organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate once in S phase. Loss of such coupling produces supernumerary centrosomes, a condition called centrosome amplification (CA). CA promotes cell invasion and chromosome instability, two hallmarks of cancer. We examined the contribution of centriole overduplication to CA and the consequences for genomic stability in breast cancer cells. CEP135, a centriole assembly protein, is dysregulated in some breast cancers. We previously identified a short isoform of CEP135, CEP135^mini, that represses centriole duplication. Here, we show that the relative level of full-length

SUBMITTER: Ganapathi Sankaran D 

PROVIDER: S-EPMC6724517 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature