High-resolution optical mapping of gastric slow wave propagation.

ABSTRACT:

Background

Improved understanding of the details of gastric slow wave propagation could potentially inform new diagnosis and treatment options for stomach motility disorders. Optical mapping has been used extensively in cardiac electrophysiology. Although optical mapping has a number of advantages relative to electrical mapping, optical signals are highly sensitive to motion artifact. We recently introduced a novel cardiac optical mapping method that corrects motion artifact and enables optical mapping to be performed in beating hearts. Here, we reengineer the method as an experimental tool to map gastric slow waves.

Methods

The method was developed and tested in 12 domestic farm pigs. Stomachs were exposed by laparotomy and stained with the voltage-sensitive fluorescence dy

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6724537 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature