<i>Drosophila</i> p53 directs nonapoptotic programs in postmitotic tissue.

ABSTRACT: TP53 is the most frequently mutated gene in human cancers, and despite intensive research efforts, genome-scale studies of p53 function in whole animal models are rare. The need for such in vivo studies is underscored by recent challenges to established paradigms, indicating that unappreciated p53 functions contribute to cancer prevention. Here we leveraged the Drosophila system to interrogate p53 function in a postmitotic context. In the developing embryo, p53 robustly activates important apoptotic genes in response to radiation-induced DNA damage. We recently showed that a p53 enhancer (p53RE^rpr) near the cell death gene reaper forms chromatin contacts and enables p53 target activation across long genomic distances. Interestingly, we found that this canoni

SUBMITTER: Kurtz P 

PROVIDER: S-EPMC6724604 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature