N-glycosylation-dependent regulation of hK_2P17.1 currents.

ABSTRACT: Two pore-domain potassium (K_2P) channels mediate potassium background currents that stabilize the resting membrane potential and facilitate action potential repolarization. In the human heart, hK_2P17.1 channels are predominantly expressed in the atria and Purkinje cells. Reduced atrial hK_2P17.1 protein levels were described in patients with atrial fibrillation or heart failure. Genetic alterations in hK_2P17.1 were associated with cardiac conduction disorders. Little is known about posttranslational modifications of hK_2P17.1. Here, we characterized glycosylation of hK_2P17.1 and investigated how glycosylation alters its surface expression and activity. Wild-type hK_2P17.1 channels and channels lacking specific glycos

SUBMITTER: Wiedmann F 

PROVIDER: S-EPMC6724686 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature