The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons.

ABSTRACT: The correlation between functional and structural neuronal plasticity is by now well documented. However, the molecular mechanisms translating patterns of neuronal activity into specific changes in the structure of neurons remain unclear. Neurotrophins can be released in an activity-dependent manner, and they are capable of controlling both neuronal morphology and functional synaptic changes. They are thus attractive molecules to be studied in the context of synaptic plasticity. In the CNS, most of the work so far has focused on the role of BDNF and of its tyrosine kinase B receptor (TrkB), but relatively little is known about the function of the pan-neurotrophin receptor p75NTR. In this study, we show in loss-of-function experiments that postnatal hippocampal pyramidal cells in two mutant

SUBMITTER: Zagrebelsky M 

PROVIDER: S-EPMC6725571 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature