Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons.

ABSTRACT: Two-pore domain potassium (K2P) channel expression is believed to underlie the developmental emergence of a potassium leak conductance [IK(SO)] in cerebellar granule neurons (CGNs), suggesting that K2P function is an important determinant of the input conductance and resting membrane potential. To investigate the role that different K2P channels may play in the regulation of CGN excitability, we generated a mouse lacking TASK-1, a K2P channel known to have high expression levels in CGNs. In situ hybridization and real-time PCR studies in wild-type and TASK-1 knock-outs (KOs) demonstrated that the expression of other K2P channels was unaltered in CGNs. TASK-1 knock-out mice were healthy and bred normally but exhibited compromised motor performance consistent with altered cerebellar function

SUBMITTER: Aller MI 

PROVIDER: S-EPMC6725905 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature