Gq/11-induced and spontaneous waves of coordinated network activation in developing frontal cortex.

ABSTRACT: Repeated episodes of spontaneous large-scale neuronal bursting and calcium influx in the developing brain can potentially affect such fundamental processes as circuit formation and gene expression. Between postnatal day 3 (P3) and P7, the immature cortex can express one such form of activation whereby a wave of neuronal activity propagates through cortical networks, generating massive calcium influx. We previously showed that this activity could be triggered by brief stimulation of muscarinic receptors. Here, we show, by monitoring large cortical areas at low magnification, that although all areas respond to muscarinic agonists to some extent, only some areas are likely to generate the coordinated wave-like activation. The waves can be triggered repeatedly in frontal areas where, as we als

SUBMITTER: Calderon DP 

PROVIDER: S-EPMC6725933 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature