Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries.

ABSTRACT:

Background

In 2014, the Centers for Medicare and Medicaid Services (CMS) began covering a multitarget stool DNA (mtSDNA) test for colorectal cancer (CRC) screening of Medicare beneficiaries. In this study, we evaluated whether mtSDNA testing is a cost-effective alternative to other CRC screening strategies reimbursed by CMS, and if not, under what conditions it could be.

Methods

We use three independently-developed microsimulation models to simulate a cohort of previously unscreened US 65-year-olds who are screened with triennial mtSDNA testing, or one of six other reimbursed screening strategies. Main outcome measures are discounted life-years gained (LYG) and lifetime costs (CMS perspective), threshold reimbursement rates, and threshold adherence rates. Outcomes are expres

SUBMITTER: Naber SK 

PROVIDER: S-EPMC6726189 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature