Akap12beta supports asymmetric heart development via modulating the Kupffer's vesicle formation in zebrafish.

ABSTRACT: The vertebrate body plan is accomplished by left-right asymmetric organ development and the heart is a representative asymmetric internal organ which jogs to the left-side. Kupffer's vesicle (KV) is a spherical left-right organizer during zebrafish embryogenesis and is derived from a cluster of dorsal forerunner cells (DFCs). Cadherin1 is required for collective migration of a DFC cluster and failure of DFC collective migration by Cadherin1 decrement causes KV malformation which results in defective heart laterality. Recently, loss of function mutation of A-kinase anchoring protein 12 (AKAP12) is reported as a high-risk gene in congenital heart disease patients. In this study, we demonstrated the role of akap12β in asymmetric heart development. The akap12β, one of the akap12 isoforms, was

SUBMITTER: Kim JG 

PROVIDER: S-EPMC6726206 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature