Antegrade Conduction Rescues Right Ventricular Pacing-Induced Cardiomyopathy in Complete Heart Block.

ABSTRACT:

Background

Right ventricular (RV) pacing-induced cardiomyopathy (PICM) occurs in ∼30% of patients with RV leads. This study evaluated the long-term effects of restoring antegrade conduction with a biological pacemaker in a porcine model of RV PICM.

Objectives

The goal of this study was to determine if antegrade biological pacing can attenuate RV PICM.

Methods

In pigs with complete atrioventricular (AV) block, transcription factor T-box 18 (TBX18) was injected into the His bundle region in either of 2 experimental protocols: protocol A sought to prevent PICM, and protocol B sought to reverse PICM. In protocol A, we injected adenoviral vectors expressing TBX18 (or the reporter construct green fluorescent protein) after AV node ablation, and observed the animals for 8 we

SUBMITTER: Dawkins JF 

PROVIDER: S-EPMC6726386 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature