A Prospective Study of Toenail Trace Element Levels and Risk of Skin Cancer.

ABSTRACT:

Background

Few epidemiologic studies have investigated trace element exposure and skin cancer risk.

Methods

Toenail levels of mercury, selenium, chromium, iron, and zinc were measured from 6,708 women in the Nurses' Health Study (1984-2012) and 3,730 men in the Health Professionals Follow-up Study (1986-2012) with data from prior nested case-control studies. Participants were free of skin cancer at toenail collection and followed for incident basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. Cox proportional hazards models were used to compute hazard ratios (HR) and 95% confidence intervals (CI) of skin cancer associated with the elements in each study. We calculated pooled multivariable HRs using a fixed-effects model. During 26 to 28 years of follow-

SUBMITTER: Matthews NH 

PROVIDER: S-EPMC6726507 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature