DNA-SWCNT Biosensors Allow Real-Time Monitoring of Therapeutic Responses in Pancreatic Ductal Adenocarcinoma.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic cancer with limited treatment options. There is an urgent need for tools that monitor therapeutic responses in real time. Drugs such as gemcitabine and irinotecan elicit their therapeutic effect in cancer cells by producing hydrogen peroxide (H₂O₂). In this study, specific DNA-wrapped single-walled carbon nanotubes (SWCNT), which precisely monitor H₂O₂, were used to determine the therapeutic response of PDAC cells in vitro and tumors in vivo. Drug therapeutic efficacy was evaluated in vitro by monitoring H₂O₂ differences in situ using reversible alteration of Raman G-bands from the nanotubes. Implantation of the DNA-SWCNT probe insid

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC6726513 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature