MiRNAs and Long-term Breast Cancer Survival: Evidence from the WHEL Study.

ABSTRACT:

Background

There is substantial variation in breast cancer survival rates, even among patients with similar clinical and genomic profiles. New biomarkers are needed to improve risk stratification and inform treatment options. Our aim was to identify novel miRNAs associated with breast cancer survival and quantify their prognostic value after adjusting for established clinical factors and genomic markers.

Methods

Using the Women's Healthy Eating and Living (WHEL) breast cancer cohort with >15 years of follow-up and archived tumor specimens, we assayed PAM50 mRNAs and 25 miRNAs using the Nanostring nCounter platform.

Results

We obtained high-quality reads on 1,253 samples (75% of available specimens) and used an existing research-use algorithm to ascertain PAM50 subtype

SUBMITTER: Natarajan L 

PROVIDER: S-EPMC6726562 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature