The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model.

ABSTRACT: In inflammatory bowel disease, chronic inflammation results in the development of colon cancer known as colitis-associated cancer. This disease is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal fibrosis is a common clinical complication that is promoted by transforming growth factor β1 (TGF-β₁). In our previous study, MA-35 attenuated renal fibrosis by inhibiting both TNF-α and TGF-β₁ signaling. This study aimed to identify the possible antitumor effects and antifibrotic effects of MA-35 using an AOM/DSS mouse model. MA-35 was orally administered every day for 70 days in the AOM/DSS mouse model. There was no difference in weight loss between the AOM/DSS group and the AOMDSS + MA-35 group, but the disease activity index score and the

SUBMITTER: Kanehara K 

PROVIDER: S-EPMC6726640 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature