Centrifugal Force-Driven Modular Micronozzle System: Generation of Engineered Alginate Microspheres.

ABSTRACT: In this study, we developed a modular micronozzle system that can control the flow of fluid based on centrifugal force and synthesize functional alginate microspheres with various structures and sizes. Our method is to fabricate a programmable microreactor that can be easily manufactured without the conventional soft-lithography process using various sequences of the micronozzles with various inner diameters. To overcome the obstacles of pump-based microfluidic devices that need to be precisely controlled, we designed the programmable microreactor to be driven under centrifugal force with a combination of micronozzles, thus enabling the mass production of various functional alginate microspheres within a few minutes. The programmable microreactor designed through the arrangement of the mod

SUBMITTER: Kang SM 

PROVIDER: S-EPMC6726759 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature