Through thick and thin: dual regulation of insect flight muscle and cardiac muscle compared.

ABSTRACT: Both insect flight muscle and cardiac muscle contract rhythmically, but the way in which repetitive contractions are controlled is different in the two types of muscle. We have compared the flight muscle of the water bug, Lethocerus, with cardiac muscle. Both have relatively high resting elasticity and are activated by an increase in sarcomere length or a quick stretch. The larger response of flight muscle is attributed to the highly ordered lattice of thick and thin filaments and to an isoform of troponin C that has no exchangeable Ca²⁺-binding site. The Ca²⁺ sensitivity of cardiac muscle and flight muscle can be manipulated so that cardiac muscle responds to Ca²⁺ like flight muscle, and flight muscle responds like cardiac muscle, showing the malleability

SUBMITTER: Bullard B 

PROVIDER: S-EPMC6726838 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature