Brain iron levels in attention-deficit/hyperactivity disorder normalize as a function of psychostimulant treatment duration.

ABSTRACT: Brain iron homeostasis is a dopamine-related mechanism that may be modified with long-term psychostimulant treatment in attention-deficit/hyperactivity disorder (ADHD). We previously reported that while medication-naïve youth with ADHD have reduced brain iron compared to controls and psychostimulant-medicated patients, no differences were detected between the latter groups. In this follow-up study, we examined whether the duration of psychostimulant treatment correlates with the degree of iron normalization. Brain iron was indexed with MRI using an advanced method called magnetic field correlation (MFC) imaging and the conventional R2* proton transverse relaxation rate method. MFC was acquired in 30 psychostimulant-medicated youth with comorbid-free ADHD and 29 age-matched controls (all ma

SUBMITTER: Adisetiyo V 

PROVIDER: S-EPMC6726915 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature