KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis.

ABSTRACT: We investigated kinase insert domain-containing receptor (KDR) polymorphisms and protein levels in relation to susceptibility to and severity of Rheumatoid Arthritis (RA). 641 RA patients and 340 controls (HC) were examined for the rs1870377 KDR variant by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method and for rs2305948 and rs2071559 KDR single nucleotide polymorphisms (SNPs) by TaqMan SNP genotyping assay. KDR serum levels were determined by enzyme-linked immunosorbent assay (ELISA). The rs1870377 KDR variant has shown association with RA under the codominant (p = 0.02, OR = 1.76, 95% CI = 1.09-2.85) and recessive models (p = 0.019, OR = 1.53, 95% CI = 1.07-2.20). KDR rs2305948 was associated with RA under the dominant model (p<

SUBMITTER: Paradowska-Gorycka A 

PROVIDER: S-EPMC6727087 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature