CC16 Levels into Adult Life Are Associated with Nitrogen Dioxide Exposure at Birth.

ABSTRACT: Rationale: Lung function and growth are adversely associated with nitrogen dioxide (NO₂) exposure. Lower levels of circulating club cell secretory protein (CC16) in childhood are also associated with subsequent decreased lung function. NO₂ exposure may induce epithelial damage in lungs and alter club cell proliferation and morphology.Objectives: To determine if increased ambient NO₂ levels at participants' home addresses in early life were associated with decreased levels of CC16 from age 6 to 32 years.Methods: Participants were enrolled at birth in the Tucson Children's Respiratory Study and had circulating CC16 measured at least once between age 6 and 32. Linear mixed models were used to determine the association between estimated amb

SUBMITTER: Beamer PI 

PROVIDER: S-EPMC6727155 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature