Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.

ABSTRACT: The placental transfer of maternal IgG is critical for infant protection against infectious pathogens. However, factors that modulate the placental transfer of IgG remain largely undefined. HIV-infected women have impaired placental IgG transfer, presenting a unique "disruption model" to define factors that modulate placental IgG transfer. We measured the placental transfer efficiency of maternal HIV and pathogen-specific IgG in US and Malawian HIV-infected mothers and their HIV-exposed uninfected and infected infants. We examined the role of maternal HIV disease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatures and their association with placental IgG transfer efficiency. Maternal IgG characteristics, such as binding to placentally expresse

SUBMITTER: Martinez DR 

PROVIDER: S-EPMC6727200 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature