GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway.

ABSTRACT:

Background

Inflammatory processes play an important role in the pathogenesis of glomerulopathies. Finding novel ways to suppress glomerular inflammation may offer a new way to stop disease progression. However, the molecular mechanisms that initiate and drive inflammation in the glomerulus are still poorly understood.

Methods

We performed large-scale gene expression profiling of glomerulus-associated G protein-coupled receptors (GPCRs) to identify new potential therapeutic targets for glomerulopathies. The expression of Gprc5b in disease was analyzed using quantitative PCR and immunofluorescence, and by analyzing published microarray data sets. In vivo studies were carried out in a podocyte-specific Gprc5b knockout mouse line. Mechanistic studies were performed in cul

SUBMITTER: Zambrano S 

PROVIDER: S-EPMC6727250 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature