The Role of the EGF Receptor in Sex Differences in Kidney Injury.

ABSTRACT:

Background

Sex differences mediating predisposition to kidney injury are well known, with evidence indicating lower CKD incidence rates and slower decline in renal function in nondiabetic CKD for premenopausal women compared with men. However, signaling pathways involved have not been elucidated to date. The EGF receptor (EGFR) is widely expressed in the kidney in glomeruli and tubules, and persistent and dysregulated EGFR activation mediates progressive renal injury.

Methods

To investigate the sex differences in response to renal injury, we examined EGFR expression in mice, in human kidney tissue, and in cultured cell lines.

Results

In wild type mice, renal mRNA and protein EGFR levels were comparable in males and females at postnatal day 7 but were significantly low

SUBMITTER: Zhang MZ 

PROVIDER: S-EPMC6727256 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature