Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data.

ABSTRACT:

Background

Decline in eGFR is a biologically plausible surrogate end point for the progression of CKD in clinical trials. However, it must first be tested to ensure strong associations with clinical outcomes in diverse populations, including patients with higher eGFR.

Methods

To investigate the association between 1-, 2-, and 3-year changes in eGFR (slope) with clinical outcomes over the long term, we conducted a random effects meta-analysis of 3,758,551 participants with baseline eGFR≥60 ml/min per 1.73 m² and 122,664 participants with eGFR<60 ml/min per 1.73 m² from 14 cohorts followed for an average of 4.2 years.

Results

Slower eGFR decline by 0.75 ml/min per 1.73 m² per year over 2 years was associated with lower risk of ESKD in pa

SUBMITTER: Grams ME 

PROVIDER: S-EPMC6727262 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature