A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome.

ABSTRACT:

Rationale

Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with "early" stage of mild acute respiratory distress syndrome (ARDS, PaO₂/FIO₂ between 200 and 300).

Objectives

To evaluate whether early NIV can reduce the need for invasive ventilation in patients with pneumonia-induced early mild ARDS.

Methods

Prospective, multicenter, randomized controlled trial (RCT) of NIV compared with conventional administration of oxygen through a Venturi mask. Primary outcome included the numbers of patients who met the intubation criteria.

Results

Two hundred subjects were randomized to NIV (n = 102) or control (n = 98) groups from 21 centers. Bas

SUBMITTER: He H 

PROVIDER: S-EPMC6727327 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature