AcrAB-TolC efflux pump system plays a role in carbapenem non-susceptibility in Escherichia coli.

ABSTRACT:

Background

Efflux pump mediated antibiotic resistance is an unnoticed and undetected mechanism in clinical microbiology laboratory. RND efflux systems are known for aminoglycoside and tetracycline resistance whereas their role in carbapenem non-susceptibility is not established. The study was undertaken to investigate the role of efflux pump in providing resistance against carbapenems and their response against concentration gradient carbapenem stress on the transcriptional level of the AcrAB gene in the clinical isolates of Escherichia coli from a tertiary referral hospital of Northeast India.

Results

Out of 298 non-susceptible Escherichia coli isolates 98 isolates were found to have efflux pump mediated carbapenem non-susceptibility. Among them thirty-five were non carbape

SUBMITTER: Chetri S 

PROVIDER: S-EPMC6727511 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature