The association between premorbid beta blocker exposure and mortality in sepsis-a systematic review.

ABSTRACT: BACKGROUND:The effect of premorbid β-blocker exposure on clinical outcomes in patients with sepsis is not well characterized. We aimed to examine the association between premorbid β-blocker exposure and mortality in sepsis. METHODS:EMBase, MEDLINE, and Cochrane databases were searched for all studies of premorbid β-blocker and sepsis. The search was last updated on 22 June 2019. Two reviewers independently assessed, selected, and abstracted data from studies reporting chronic β-blocker use prior to sepsis and mortality. Main data extracted were premorbid β-blocker exposure, mortality, study design, and patient data. Two reviewers independently assessed the risk of bias and quality of evidence. RESULTS:In total, nine studies comprising 56,414 patients with sepsis including 6576 patients wit

SUBMITTER: Tan K 

PROVIDER: S-EPMC6727531 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature