Mycelyso - high-throughput analysis of Streptomyces mycelium live cell imaging data.

ABSTRACT:

Background

Streptomycetes are filamentous microorganisms of high biotechnological relevance, especially for the production of antibiotics. In submerged cultures, the productivity of these microorganisms is closely linked to their growth morphology. Microfluidic lab-on-a-chip cultivation systems, coupled with automated time-lapse imaging, generate spatio-temporal insights into the mycelium development of streptomycetes, therewith extending the biotechnological toolset by spatio-temporal screening under well-controlled and reproducible conditions. However, the analysis of the complex mycelial structure formation is limited by the extent of manual interventions required during processing of the acquired high-volume image data. These interventions typically lead to high evaluation time

SUBMITTER: Sachs CC 

PROVIDER: S-EPMC6727546 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature