Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs.

ABSTRACT:

Background

Solid tumors produce proteins that can induce the accumulation of bone marrow-derived cells in various tissues, and these cells can enhance metastatic tumor growth by several mechanisms. 4T1 murine mammary tumors are known to produce granulocyte colony-stimulating factor (G-CSF) and increase the numbers of immunosuppressive CD11b⁺Gr1⁺ myeloid-derived suppressor cells (MDSCs) in tissues such as the spleen and lungs of tumor-bearing mice. While surgical resection of primary tumors decreases MDSC levels in the spleen, the longevity and impact of MDSCs and other immune cells in the lungs after tumor resection have been less studied.

Methods

We used mass cytometry time of flight (CyTOF) and flow cytometry to quantify MDSCs in the spleen, periphera

SUBMITTER: Bosiljcic M 

PROVIDER: S-EPMC6727565 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature