Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy.

ABSTRACT:

Background

Preclinical evidence suggests that low-dose radiation may overcome the inhibitory effects of the tumor stroma and improve a tumor's response to immunotherapy, when combined with high-dose radiation to another tumor. The aim of this study was to evaluate tumor responses to this combination in a clinical setting.

Methods

A post-hoc analysis of 3 ongoing immunoradiation trials was performed. Twenty-six (of 155) patients received low-dose radiation (1-20 Gy total), either as scatter from high-dose radiation or from intentional treatment of a second isocenter with low-dose radiation, were evaluated for response. The low-dose lesions were compared to lesions that received no radiation (< 1 Gy total). Response rates, both defined as complete and partial responses as defi

SUBMITTER: Menon H 

PROVIDER: S-EPMC6727581 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature