Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection.

ABSTRACT: Acinetobacter baumannii is currently considered one of the most problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections. Furthermore, data revealed that the hisF gene, implicated in the innate immunity and inflammation, is involved in virulence during a pneumonia infect

SUBMITTER: Martinez-Guitian M 

PROVIDER: S-EPMC6727670 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature