Association of National Cancer Institute-Sponsored Clinical Trial Network Group Studies With Guideline Care and New Drug Indications.

ABSTRACT:

Importance

National Cancer Institute Clinical Trial Network (NCTN) groups serve a vital role in identifying effective new antineoplastic regimens. However, the downstream clinical effect of their trials has not been systematically examined.

Objective

To examine the association of NCTN trials with guideline care and new drug indications.

Design, setting, and participants

This retrospective cohort study evaluated phase 3 SWOG Cancer Research Network clinical trials from January 1, 1980, through June 30, 2017. Only completed trials with published results were included. To be considered practice influential (PI), a trial must have been associated with guideline care through its inclusion in National Comprehensive Cancer Network (NCCN) clinical guidelines or US Food and Dr

SUBMITTER: Unger JM 

PROVIDER: S-EPMC6727679 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature