Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial.

ABSTRACT:

Importance

The patterns of disease recurrence after resection of pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear.

Objective

To define patterns of recurrence after adjuvant chemotherapy and the association with survival.

Design, setting, and participants

Prospectively collected data from the phase 3 European Study Group for Pancreatic Cancer 4 adjuvant clinical trial, an international multicenter study. The study included 730 patients who had resection and adjuvant chemotherapy for pancreatic cancer. Data were analyzed between July 2017 and May 2019.

Interventions

Randomization to adjuvant gemcitabine or gemcitabine plus capecitabine.

Main outcomes and measures

Overall survival, recurrence, and sites of recurrence.

Results

SUBMITTER: Jones RP 

PROVIDER: S-EPMC6727687 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature