Preterm birth subtypes, placental pathology findings, and risk of neurodevelopmental disabilities during childhood.

ABSTRACT:

Introduction

Preterm birth (PTB) and in-utero inflammation are recognized risk factors of neurodevelopmental disabilities (NDDs); however, their combined role in NDDs is unknown. We examined the independent and joint association of PTB and placental histological findings with the childhood risk of NDDs (overall and by subgroups including autism spectrum disorder (ASD) and ADHD).

Methods

We analyzed data from the Boston Birth Cohort, where mother-infant pairs were enrolled at birth and followed from birth onwards. Birth outcomes, placental pathology and NDDs were obtained from electronic medical records. Placental pathology was categorized using a standardized classification system proposed by the Amsterdam Placental Workshop Group.

Results

PTB (all, including spontane

SUBMITTER: Raghavan R 

PROVIDER: S-EPMC6727987 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature